Clinical library · PMX-000
Mechanism, half-life, trial endpoints, interaction boxes - extracted from FDA labels into one file per molecule. No checkout. No manufacturer rankings.
Choose a clinical lane - each monograph ships with a stable PMX code for citation.
One pathway, three agents - half-life and meal timing separate them more than potency slides suggest.
Spasticity and neuropathic pain sit in adjacent chapters of the formulary - different receptors, different monitoring.
Glucocorticoid taper mechanics and weight-based ivermectin - the details that separate a passing answer from a safe order.
When the clinical question outgrows a single strength line.
Pathway logic: arousal requirement, nitrate contraindication, and how vascular comorbidity constrains choice.
Read article PMX-004ANDA bioequivalence thresholds, Orange Book AB ratings, and why overseas tablets aren't U.S. generics.
Read articlePharmacology Maximum exists for the reader who wants the label depth without the label layout. Each monograph stacks mechanism, ADME, registration trial data, dose limits, and contraindications in one file - the way a good journal club handout should read.
No industry funding. Trade names point to molecules, not endorsements.
Built for pharmacy students, residents, and clinicians who need more than a pocket card but less than rereading the entire PI every time.
Current FDA label first - boxed warnings, PK tables, dose bands - then the registration trials referenced in that label. ADME grids and timelines appear when they'd replace a back-of-envelope calculation.
Off-label patterns overseas get flagged when they affect counseling. Not to prescribe abroad - to stop surprise questions in clinic.
Label supplement drops tomorrow? The PDF overrides us. Treat these pages as annotated maps.
Library guides follow intro → mechanism → PK → trials → dosing → interactions → adverse effects → special populations → bottom line. Articles PMX-004 and PMX-005 handle class-level questions - bioequivalence, pathway - that no single strength line covers.
Cite the PMX code in coursework. Related links at the bottom are further reading, not prescribing shortcuts.
Monographs live at /library/. Class articles at /articles/. Legal pages at /legal/.
Extended guides include a sticky sidebar table of contents on wide screens.
Condensed cross-links - complete PK tables sit inside each PMX monograph.
Oral PDE5 agents remain first-line pharmacologic options for ED where approved. Shared cGMP mechanism; divergent half-lives and food effects.
Bench potency rankings make great exam fodder. At labeled doses most men respond similarly - bioavailability and binding kinetics flatten the IC50 story.
Nitrates contraindicate the entire class. Longer half-life doesn't carve out an exception.
Gabapentin and tizanidine occupy overlapping clinical niches with zero mechanistic overlap. Alpha-2-delta subunit binding versus central alpha-2 agonism. CrCl-driven dosing versus CYP1A2 landmines.
Sedation stacks with opioids on gabapentin. Hypotension stacks with fluoroquinolones on tizanidine. Different drugs, different vigilance.
Prednisolone is pharmacologically active as administered - no hepatic activation step like prednisone. Long courses demand taper, not abrupt stop.
Ivermectin dosing varies by indication; scabies regimens are weight-based. Veterinary paste introduces concentration errors that poison control sees too often.
Registration trials anchor our citations: IIEF endpoints for PDE5 agents, Ashworth scales for tizanidine.
ED trial placebo response runs high. Reported effect sizes inflate if you pretend the placebo arm didn't exist.
Post-approval label revisions - QT language, respiratory depression warnings - supersede what you memorized in school. The PI remains authoritative.
PMX-001 through PMX-009 - fixed identifiers for syllabi, journal clubs, and slide citations.
Nitroglycerin in the ambulance bay plus a cheap generic sildenafil from last night - that combination kills the same way innovator Viagra does. Food delays onse…
Half-life near 17.5 hours is the whole brand story - a PRN dose can cover a weekend window, and 2.5 mg daily can blur the kitchen-timer relationship with interc…
Highest in vitro PDE5 potency in the class - and in clinic vardenafil behaves like its cousins when doses stay labeled. The ward-relevant differences are lower …
Tizanidine lowers spasticity in multiple sclerosis and spinal cord injury by turning down excitatory signaling in spinal interneurons. It is not a peripheral ne…
Card note: a diabetic with eGFR 28 on 900 mg TID gabapentin lands in the ED somnolent and ataxic - not because gabapentin is hepatotoxic, but because nobody rec…
A parent draws 'one teaspoon' from a 15 mg/5 mL Prelone bottle when the prescription was written for 5 mg/5 mL - triple overdose from identical cherry liquid, n…
The scabies callback at day 21 is almost always a skipped day-14 dose, not resistant mites - eggs hatch on a schedule your patient does not remember once the it…
The pharmacy call is always the same: "Is this the same as Viagra?" For AB-rated generics the regulatory answer is yes on population PK - and for the man who to…
The pill did nothing - because he took it after steak, skipped foreplay, and expected an erection without stimulation. PDE5 inhibitors extend cGMP when nitric o…
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